Neurological Centres


The Center supports extensive research activities including clinical trials, translational research and basic research.
  • Participation in Clinical Trials – the APOLLO, HELIOS and neuroTTRansform trials for patients with Familial Amyloid Polyneuropathy since January 2015
  • Clinical-epidemiological studies focusing on rare neuromuscular disorders including clinical phenotype, phenotype/genotype correlations, familial clustering and epidemiology of ALS, Charcot-Marie-Tooth Disease, myasthenia, etc.
  • Biomarker discovery studies including studies in myotonic dystrophy and inherited neuropathies
  • Genetic studies (NGS, family studies, etc)
  • Gene expression studies in cell cultures and experimental models in order to clarify the cellular and molecular effects of disease causing mutations
  • Basic Research: Experimental models of inherited neuropathy, CMT disease mechanisms, testing of innovative therapies, gene therapy targeting peripheral nerves and the central nervous system

Selected publications of the Neuromuscular Disorders Center in the last 5 years:

  1. Parissis D, Christodoulou K, Kleopa KA. Novel de novo DNMT1 gene mutation associated with hereditary sensory and autonomic neuropathy 1E (HSAN1E). Neurol Sci. 2023 Feb 6.
  2. Adams D, Tournev IL, Taylor MS, Coelho T, Planté-Bordeneuve V, Berk JL, González-Duarte A, Gillmore JD, Low SC, Sekijima Y, Obici L, Chen C, Badri P, Arum SM, Vest J, Polydefkis M; HELIOS-A Collaborators. Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial. Amyloid. 2022 Jul 23:1-9. 
  3. Topaloudi A, Zagoriti Z, Flint AC, Martinez MB, Yang Z, Tsetsos F, Christou YP, Lagoumintzis G, Yannaki E, Zamba-Papanicolaou E, Tzartos J, Tsekmekidou X, Kotsa K, Maltezos E, Papanas N, Papazoglou D, Passadakis P, Roumeliotis A, Roumeliotis S, Theodoridis M, Thodis E, Panagoutsos S, Yovos J, Stamatoyannopoulos J, Poulas K, Kleopa K, Tzartos S, Georgitsi M, Paschou P.  Myasthenia gravis genome-wide association study implicates AGRN as a risk locus. J Med Genet. 2022 Aug;59(8):801-809.
  4. Chroni E, Kleopa KA. Editorial: Update on the Diagnosis and Management of CIDP Variants. Front Neurol. 2021 Nov 24;12:796841.
  5. Tziakouri A, Natsiopoulos K, Kleopa KA, Michaelides C.  Transient, Recurrent Central Nervous System Clinical Manifestations of X-Linked Charcot-Marie-Tooth Disease Presenting with Very Long Latency Periods between Episodes: Is Prolonged Sun Exposure a Provoking Factor? Case Rep Neurol Med. 2020 Jun 27;2020:9753139.
  6. Georgiou A, Demetriou CA, Christou YP, Heraclides A, Leonidou E, Loukaides P, Yiasoumi E, Pantziaris M, Kleopa KA, Papacostas SS, Loizidou MA, Hadjisavvas A, Zamba-Papanicolaou E. Genetic and Environmental Factors Contributing to Parkinson's Disease: A Case-Control Study in the Cypriot Population. Front Neurol. 2019 Oct 17;10:1047.
  7. Leonidou E, Pantzaris M, Kleopa KA, Loizidou MA, Kyriakides T, Christou YP. Postgrad Med. 2019 Sep;131(7):486-489. Postgrad Med. 2019 Sep;131(7):486-489.
  8. Demetriou CA, Hadjivasiliou PM, Kleopa KA, Christou YP, Leonidou E, Kyriakides T, Zamba-Papanicolaou E. Retrospective longitudinal study of ALS in Cyprus: Clinical characteristics, management and survival.  PLoS One. 2019 Sep 6;14(9):e0220246.
  9. Lambrianides S, Demetriou CA, Tillyris A, Kkolou E, Gaglia E, Agkastinioti E, Leonidou E, Christou YP, Papacostas SS, Kleopa KA, Kyriakides T, Pantzaris M. Prevalence of Anti-JC Virus (JCV) Antibodies in the Multiple Sclerosis (MS) Population in Cyprus: A Retrospective Study.  Neurol Res Int. 2019 Aug 14;2019:3741260.
  10. Christou YP, Tanteles GA, Kkolou E, Ormiston A, Konstantopoulos K, Beconi M, Marshall RD, Plotkin H, Kleopa KA. Open-Label Fosmetpantotenate, a Phosphopantothenate Replacement Therapy in a Single Patient with Atypical PKAN. Case Rep Neurol Med. 2017;2017:3247034.
  11. Konstantopoulos K, Christou YP, Vogazianos P, Zamba-Papanicolaou E, Kleopa KA. A quantitative method for the assessment of dysarthrophonia in myasthenia gravis. J Neurol Sci. 2017 Jun 15;377:42-46.