The Neuropathology Department mission is to function as a tertiary service where patients with neurodegenerative conditions of both the peripheral and central nervous systems, can attend for assessment, diagnosis and long-term management. The Department has active research projects exploring the potential strong association between cognition and the metabolic syndrome in pre-clinical mouse models of Alzheimer’s Disease. Furthermore, and spurred on from the clinical expertise the Department’s Head has in neuromuscular and neurogenetic conditions, it is setting up a patient-derived induced pluripotent stem cell (iPSC) pipeline for generation of cellular models that will enable the study of disease pathomechanisms and explore applied therapeutics. iPSCs derived from reprogramming patient-derived somatic cells and their subsequent differentiation to cells relevant to the observed phenotype, fully recapitulate the individual genetic variation and characteristics which lead to the observed phenotypic trait in the patient donor and are an invaluable tool for studying inherited human diseases, and particularly those in which animal models of pathomechanisms are not fully established.’

Contact Person: Dr. Menelaos Pipis ([email protected])