Neuroepidemiology Department

2017

• Demetriou, C.A., Heraclides, A., Salafori, C., Tanteles, G.A., Christodoulou, K., Christou, Y. and Zamba-Papanicolaou, E. (), Epidemiology of Huntington Disease in Cyprus: A 20-Year Retrospective Study. Clin Genet. Accepted Author Manuscript. doi:10.1111/cge.13168
• Georgiou A, Demetriou CA, Heraclides A, Christou YP, Leonidou E, Loukaides P, Yiasoumi E, Panagiotou D, Manoli P, Thomson P, Loizidou MA, Hadjisavvas A, Zamba-Papanicolaou E. Mitochondrial superclusters influence age of onset of Parkinson's disease in a gender specific manner in the Cypriot population: A case-control study. PLoS One. 2017 Sep 6;12(9):e0183444. doi: 10.1371/journal.pone.0183444. 
• Demetriou CA, Hadjivasiliou PM, Kleopa KA, Christou YP, Leonidou E, Kyriakides T, Zamba-Papanicolaou E. Epidemiology of amyotrophic lateral sclerosis in the republic of cyprus: a 25-year retrospective study. Neuroepidemiology 2017;48:79-85 (DOI: 10.1159/000477126) 
• Koutsoulidou A, Photiades M, Kyriakides TC, Georgiou K, Prokopi M, Kapnisis K, Lusakowska A, Nearchou M, Christou Y, Papadimas GK, Anayiotos A, Kyriakou K, Kararizou E, Zamba Papanicolaou E, Phylactou LA. Identification of exosomal muscle-specific miRNAs in serum of myotonic dystrophy patients relating to muscle disease progress. Hum Mol Genet. 2017 Sep 1;26(17):3285-3302. doi: 10.1093/hmg/ddx212.
   

2016

• Varda E, Demetriou CA, Heraclides A, Christou YP, Zamba-Papanicolaou E. Quality of Life of Cypriot Patients Suffering with Huntington’s Disease. PLoS Curr. 2016 October 25; 8: ecurrents.hd.270776c4fdd7776499dd45bf47049a75.
• Stergiou C, Lazaridis K, Zouvelou V, Tzartos J, Mantegazza R, Antozzi C, Andreetta F, Evoli A, Deymeer F, Saruhan-Direskeneli G, Durmus H, Brenner T, Vaknin A, Berrih-Aknin S, Behin A, Sharshar T, De Baets M, Losen M, Martinez-Martinez P, Kleopa KA, Zamba-Papanicolaou E, Kyriakides T, Kostera-Pruszczyk A, Szczudlik P, Szyluk B, Lavrnic D, Basta I, Peric S, Tallaksen C, Maniaol A, Gilhus NE, Casasnovas Pons C, Pitha J, Jakubíkova M, Hanisch F, Bogomolovas J, Labeit D, Labeit S, Tzartos SJ. “Titin antibodies in   seronegative myasthenia gravis - A new role for an old antigen”.  Journal of Neuroimmunology. 2016 Mar 15;292:108-15. doi: 10.1016/j.jneuroim.2016.01.018.

2015

• Andrie Koutsoulidou, Tassos C. Kyriakides, George K. Papadimas, Yiolanda Christou, Evangelia Kararizou, Eleni Zamba-Papanicolaou, Leonidas A. Phylactou. Elevated Muscle-Specific miRNAs in Serum of Myotonic Dystrophy Patients Related to Muscle Disease Progress. Koutsoulidou et al. PLoS One. 2015 Apr 27;10(4):e0125341. doi: 10.1371/journal.pone.0125341.
• Nicolaou Paschalis, Koutsou Lina, Georghiou Anthi, Anastasiadou Violetta,  Tanteles George, Kyriakdies Theodoros, Papanicolaou-Zamba Eleni. “Genetic findings of Cyprus Spinal Muscular Atrophy patients”. Journal of Neurology 2015 Oct;36(10):1829-34. doi: 10.1007/s10072-015-2263-5.

2014

• Christina Votsi, Eleni Zamba-Papanicolaou, Lefkos T. Middleton, Marios Pantzaris and Kyproula Christodoulou. A Novel GBA2 Gene Missense Mutation in Spastic Ataxia. Annals of Human Genetics (2014) 78, 13-22.

2013

• Nicolaou P, Cianchetti C, Minaidou A, Marrosu G, Zamba-Papanicolaou E, Middleton L, Christodoulou K. A  novel LRSAM1 mutation is associated with autosomal dominant axonal Charcot-Marie-Tooth disease. Eur J Hum Genet. 2013 Feb;21(2):190-4, doi:10.1038/ejhg.2012.146. PMID: 22781092
• P. Zisimopoulou, P. Evangelakou, J. Tzartos, K. Lazaridis, V. Zouvelou, R.  Mantegazza, C. Antozzi, F. Andreetta, A. Evoli, F. Deymeer, G. Saruhan-Direskeneli, H. Durmus, T. Brenner, A. Vaknin, S. Berrih-Aknin, M. Frenkian Cuvelier, T. Stojkovic, M. DeBaets, M. Losen i, P. Martinez-Martinez, K. A. Kleopa, E. Zamba-Papanicolaou, T. Kyriakides, A. Kostera-Pruszczyk, P. Szczudlik, B. Szyluk, D. Lavrnic, I. Basta, S. Peric, C. Tallaksen, A. Maniaol, S.J. Tzartos. Comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis. Journal of Autoimmunity 2014 Aug;52:139-45. doi: 10.1016/j.jaut.2013.12.004

2012

• Nicolaou P, Cianchetti C, Minaidou A, Marrosu G, Zamba-Papanicolaou E,Middleton L, Christodoulou K. A novel LRSAM1 mutation is associated with autosomal dominant axonal Charcot-Marie-Tooth disease. Eur J Hum Genet. 2013 Feb;21(2):190-4, doi:10.1038/ejhg.2012.146. PMID: 22781092
• Votsi C, Zamba-Papanicolaou E, Georghiou A, Kyriakides T, Papacostas S, Kleopa KA, Pantzaris M, Christodoulou K. Investigation of SCA10 in the Cypriot population: Further exclusion of SCA dynamic repeat mutations. J Neurol Sci. 2012 Dec 15;323(1-2):154-7 
• Papathanasiou ES, Zamba-Papanicolaou E. A comparison between disposable and reusable single fibre needle electrodes in relation to stimulated single fibre studies. Clin Neurophysiol. 2012 Jul;123(7):1437-9

2011

• Kyriakides T, Papacostas S, Papanicolaou E, Bagdades E, Papathanasiou ES. Sleep hypoventilation syndrome and respiratory failure due to multifocal motor neuropathy with conduction block. Muscle Nerve 2011;43(4):610‐4 
• Dardiotis E, Papathanasiou E, Vonta I, Hadjigeorgiou G, Zamba-Papanicolaou E, Kyriakides T. A correlative study of quantitative EMG and biopsy findings in 31 patients with myopathies.  Acta Myol. 2011 Jun;30(1):37-41

2010 and before

• Nicolaou P, Zamba-Papanicolaou E, Koutsou P, Kleopa KA, Georghiou A, Hadjigeorgiou G, Papadimitriou A, Kyriakides T, Christodoulou K. Charcot-Marie-Tooth disease in Cyprus: epidemiological, clinical and genetic characteristics. Neuroepidemiology 2010 June 23;35(3):171-177. PMID: 20571287 
• Mintchev N, Zamba-Papanicolaou E, Kleopa K, Christodoulou K. A novel ALS2 splice-site mutation in a Cypriot juvenile-onset primary lateral sclerosis family. Neurology. 2009 Jan 6;72(1):28-32. PMID: 19122027 
• Zamba-Papanicolaou E, Koutsou P, Daiou C, Gaglia E, Georghiou A, Christodoulou K. High frequency of Friedreich’s ataxia carriers in the Paphos district of Cyprus. Acta Myol. 2009 Jul;28(1):24-26. PMID: 19772192
• Dardiotis E., Koutsou P., Papanicolaou E., Vonta I., Kladi D., Vassilopoulos D., 
• Hadjigeorgiou G., Christodoulou K., Kyriakides T., Epidemiological, clinical and genetic study of Familial Amyloidotic Polyneuropathy in Cyprus. Amyloid. 2009 Mar;16(1):32-7. 
• Dardiotis E, Koutsou P, Zamba-Papanicolaou E, Vonta I, Hadjivassiliou M,    Hadjigeorgiou G, Cariolou M, Christodoulou K, Kyriakides T. Complement C1Q polymorphisms modulate onset in familial amyloidotic polyneuropathy TTR Val30Met. J Neurol Sci. 2009 Sep 15;284 (1-2):158-62. 
• Papathanasiou ES, Zamba-Papanicolaou E. Differential orbicularis oculi involvement in neuromuscular junction dysfunction. Journal of Clinical Neurophysiology 2008;25:293-298 
• Nicolaou P, Georghiou A, Votsi C, Middleton LT, Zamba-Papanicolaou E, Christodoulou K. A novel c.5308_5311delGAGA mutation in Senataxin in a Cypriot family with an autosomal recessive cerebellar ataxia. BMC Med Genet. 2008 Apr 14;9(1):28. PMID: 18405395 
• Kleopa KA, Zamba-Papanicolaou E, Alevra X, Nicolaou P, Georgiou DM, Hadjisavvas A, Kyriakides T, Christodoulou K. Phenotypic and cellular expression of two novel connexin32 mutations causing CMT1X. Neurology 2006 66: 396-402. PMID: 16476939 
• Sivakumar K, Kyriakides T, Puls I, Nicholson GA, Funalot B, Antonellis A, llsworth E, Sambuughin N, Christodoulou K, Beggs JL, Zamba-Papanicolaou E, Ionasescu V, Dalakas MC, Green ED, Fischbeck KH, Goldfarb LG. Phenotypic spectrum of disorders associated with glycyl-tRNA synthetase mutations. Brain. 2005 Oct; 128(Pt 10): 2304-14. 
• Kleopa KA, Kyriacou K, Zamba-Papanicolaou E, Kyriakides T. Reversible  inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease. Muscle Nerve. 2004 Aug 18.
• Papathanasiou ES, Pantzaris M, Zamba-Papanicolaou E, Kyriakides T, KA, Iliopoulos I, Piperidou C, Papacostas S. Neurogenic vestibular evoked potentials in the diagnosis of multiple sclerosis. Electromyogr Clin Neurophysiol. 2004 Jul-Aug; 44(5): 313-7.
• Papathanasiou ES, Zamba-Papanicolaou E, Pantzaris M, Kleopas K, Kyriakides T, Papacostas S, Pattichis C, Iliopoulos I, Piperidou C. Neurogenic vestibular evoked potentials using a tone pip auditory stimulus. Electromyogr Clin Neurophysiol. 2004 Apr-May; 44(3): 167-73.
• Papathanasiou E, Zamba-Papanicolaou E, Pantzaris M, Kyriakides T,  Papacostas S, Myrianthopoulou P, Pattichis C, Iliopoulos I, Piperidou C. Click evoked neurogenic vestibular potentials (NVESTEPs): a method of assessing the function of the vestibular system. Electromyogr Clin Neurophysiol. 2003 Oct-Nov;43(7):399-408. 
• Zamba-Papanicolaou E, Christodoulou K, Christodoulou C, Kyriakides T, Middleton LT. Hereditary Motor Neuronopathies. Rev Neurol (Paris). 2002 Dec; 158(121):1220-1224. PMID: 12690745 
• Christodoulou K, Deymeer F, Serdaroğlu P, Ozdemir C, Poda M, Georgiou DM, Ioannou P, Tsingis M, Zamba E, Middleton LT. Mapping of the second Friedreich's ataxia (FRDA2) locus to chromosome 9p23-p11: evidence for further locus heterogeneity. Neurogenetics. 2001 Jul;3(3):127-32. PMID:11523563 
• Zamba E, Christodoulou K, Al-Qudah AK, Horani K, Kyriakides T, Middleton LT, Mubaidin A. Autosomal recessive distal hereditary motor neuropathies. Acta Myol 2001 May; Vol. XX:53-56.
• Georgiou DM, Jedrzejowska H< Ryniewicz B, Hausmanowa-Petrucewicz I, Zamba E, Kyriakides T, Christodoulou K, Middleton LT. Molecular genetic studies in axonal AR-CMT. Acta Myol 2001 May; Vol XX35-38.
• Papathanasiou ES, Zamba E, Papacostas SS. Radial nerve F-waves: normative values with surface recording from the extensor indicis muscle.  Neurophysiology 2001 Jan; 112(1): 145-52. 
• Christodoulou K, Zamba E, Tsingis M, Mubaidin A, Horani K, Abu-Sheik S, El-Khateeb M, Kyriacou K, Kyriakides T, Al-Qudah AK, Middleton LT (2000) A novel form of distal hereditary motor neuronopathy (HMN-J) maps to chromosome 9p21.1-p12. Ann Neurol 48(6): 877-884. 
• Zamba E, Christodoulou K, Al-Shehab A, Mubaidin A, Neocleous V, Tsingis M, Abu-Sheik S, Middleton L, Horany K, Al-Qudah AK. Clinical and genetic heterogeneity in autosomal recessive CMS Jordanian families. Acta Myol. 2000 April Vol. XIX:37-40.
• Christodoulou K, Neocleous V, Tsingis M, Pantzaris M, Kyriallis K, Zamba E, Bairactaris C, Mavrommatis I, Middleton L, Mylonas I. Autosomal recessive congenital myasthenic syndrome in three Greek-Gypsy families. Acta Myol. 2000 Vol. XIX:41-43.
• Middleton L, Ohno K, Christodoulou K, Brengman J, Milone M, Neocleous V,Serdaroğlu P, Deymeer F, Ozdemir C, Mubaidin A, Horany K, Al-Shehab A, Mavromatis I, Mylonas I, Tsingis M, Zamba E, Pantzaris M, Kyriallis K, Engel AG. Chromosome 17p-linked myasthenias stem from defects in the acetylcholine receptor epsilon-subunit gene. Neurology. 1999 Sep 22;53(5):1076-82. PMID: 10496269 
• Middleton LT, Christodoulou K, Mubaidin A, Zamba E, Tsingis M, Kyriacou K, Abu-Sheikh S, Kyriakides T, Neocleous V, Georgiou DM, Eel-Khateeb M, Aal-Qudah A, Horany K. Distal hereditary motor neuronopathy of the Jerash type. Ann N Y Acad Sci. 1999 Sep 14;883:65-8 PMID: 10586232 
• Middleton LT, Christodoulou K, Deymeer F, Serdaroglu P, Ozdemir C, al-Qudah AK, al-Shehab A, Mavromatis I, Mylonas I, Evoli A, Tsingis M, Zamba E, Kyriallis K. Congenital myasthenic syndrome. (CMS) type Ia. Clinical and genetic diversity. Ann N Y Acad Sci. 1998 May 13;841:157-66. PMID: 9668234 
• Middleton LT, Pantzaris M, Zambe E, Kyriallis K, Christoulou K. Inherited Myasthenic Syndromes. Acta Myologica. 1998 Dec Vol. II:47-53.
• Kyriakides T, Christodoulou K, Zamba E, Middleton L. Hereditary motor  Neurophysiological, clinical, neurophysiological and genetic aspects. Acta Myolgica. 1998 Dec Vol.II:55-58.