Neuroepidemiology Department


The main research interests of the Neuro-epidemiology Department include:

Participation in Clinical Trials (OLE, Helios, IONIS): Clinical Trials for patients with Familial Amyloid Polyneuropathy (FAP) since 2015. 

Rare Neurological Disease: Investigation of phenotype/genotype correlations, clinical phenotypes, familiar clustering and epidemiology of rare disease such as Huntington ’s disease and Amyotrophic Lateral Sclerosis. 

The Department is also interested in the genomics, proteomics and metabolomics and epigenomics of both rare diseases (HD and ALS) and more complex diseases such as PD.

The clinical members have become Regular Members of the European Huntington’s Disease Network (EHDN). 

Neuromuscular Diseases: Investigation of the phenotype, phenotype/genotype correlations, epidemiology and genomics, SNPs and methyl-omics of neuromuscular diseases such as ALS, Ataxias and FAP. 

The Neuroepidemiology Department focuses on designing and conducting studies investigating the distribution and determinants of genetics, molecular and environmental factors of various neurological disease such as Amyotrophic Lateral Sclerosis (ALS), Parkinson’s Disease (PD), Huntington’s Disease (HD), Ataxia’s. Some of the publications of the department include: 

  1. Retrospective longitudinal study of ALS in Cyprus: Clinical characteristics, management and survival., Christiana A. Demetriou, Petros M. Hadjivasiliou, Kleopas A. Kleopa, Yiolanda P. Christou, Eleni Leonidou, Theodoros Kyriakides, Eleni Zamba-Papanicolaou. (2019, PLOS ONE). 
  2. Epidemiology of Huntington disease in Cyprus: A 20-year retrospective study., C A Demetriou ,A Heraclides, C Salafori, G A Tanteles, K Christodoulou, Y Christou, E Zamba-Papanicolaou. (2017, Clinical Genetics). 
  3. Quality of Life in Cypriot Patients Suffering with Huntington’s Disease., Eleni Varda, Christiana A. Demetriou, Alexandros Heraclides, Yiolanda P. Christou, and Eleni Zamba-Papanicolaou. (2016, PLOS Currents). 
  4. Genetics and Environmental Factors contributing to Parkinsons Disease: A case-control study in the Cypriot Population., Andrea Georgiou , Christiana A Demetriou, Yiolanda P Christou 1, Alexandros Heraclides, Eleni Leonidou , Panayiotis Loukaides, Elena Yiasoumi, Marios Pantziaris , Kleopas A Kleopa , Savvas S Papacostas, Maria A Loizidou, Andreas Hadjisavvas , Eleni Zamba-Papanicolaou , (2019, Frontiers in Neurology). . 
  5. Mitochondrial superclusters influence age of onset¬ of Parkinson’s Disease in gender specific manner in the Cypriot population: A case-control study., Andrea Georgiou, Christiana A. Demetriou, Alexandros Heraclides, Yiolanda P. Christou, Eleni Leonidou, Panayiotis Loukaides, Elena Yiasoumi, Dimitris Panagiotou, Panayiotis Manoli, Pippa Thomson, Maria A. Loizidou, Andreas Hadjisavvas, Eleni Zamba-Papanicolaou., (2017, PLOS ONE) 
  6.  Investigating the transition of pre-symptomatic to symptomatic Huntington’s Disease Status based on omics data., Christiana C Christodoulou , Margarita Zachariou, Marios Tomazou , Evangelos Karatzas, Christiana A. Demetriou, Eleni Zamba Papanicolaou, George M. Spyrou, (2020, International Journal of Molecular Science). 
  7.  Revealing clusters of connected pathways through multisource data integration in Huntington’s Disease and Spastic Ataxia., Andrea C. Kakouri, Christiana C. Christodoulou, Margarita Zachariou, Anastasis Oulas, George Minadakis, Christiana A. Demetriou , Christina Votsi, Eleni Zamba-Papanicolaou , Kyproula Christodoulou , and George M. Spyrou., (2019, IEEE Journal of biomedical and health informatics). 


2018-today Malekkou A, Samarani M, Drousiotou A, Votsi C, Sonnino S, Pantzaris M, Chiricozzi E, Zamba-Papanicolaou E, Aureli M, Loberto N, Christodoulou ...


Research Grants to the Neuroepidemiology Department:    Seed Fund from the European Huntington’s Disease Network-“Untargeted ...