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Neuropathology Department

Publications

  1. Kyriakides T, Langton Hewer R.  Hand contractures in Parkinson's Disease.  Journal of Neurology,        Neurosurgery and Psychiatry 1988; 51:1221-1223
  2. Kyriakides T, Aziz T Z, Torrens M J.  Postoperative recovery of third nerve Palsy due to posterior    communicating neurysms. British Journal of Neurosurgery 1989; 3:109-112
  3. Anderson N A B, Kyriakides T, Pamphilon D H, Campbell M J.  Plasma exchange in Refsum's Disease; case report and review of the  literature. 
  4. Transfusion Science 1989; 10:63-6810 Anderson N A B, Kyriakides T, Fergusson I T, Wallington T B Plasma Exchange in the Treatment of Guillain-Barre Syndrome:  Experience  in a Sub-regional Referral Unit.  Postgrad Med J 1991; 67:154-156.                                                                                                                               
  5. Kyriakides T, Hallam L A, Hockey A, Silberstein P, Kakulas B A.     “Angleman’s Syndrome"; A neuropathological study.  Acta  Neuropathological 1992; 83:675-678                                                                                                                                               
  6. Kyriakides T, Silberstein J M, Jonpiputranich S, Silberstein P, Walsh P, Gubbay S,Kakulas B A.    The significance of Type 1 fibre Predominance  Muscle & Nerve 1993; 16:418-423
  7. Kyriakides T.  The use of multiple anti-dystrophin antibodies in Duchenne and Becker muscular dystrophy.     Journal of Neurology, Neurosurgery and Psychiatry 1993;  Vol 56, 10, 1137
  8. Kyriakides T, Middleton L T   The Magnitude of the Problem: Stroke from Carotid Bifurcation Disease without  Premonitory Transient Ischaemic Attacks. In Berstein EF, Callow AD,  
  9. Nicolaides A N, Shifrin E G (eds)  Cerebral Revascularization Med-Orion Publishing Company, London, Los Angeles, Nicosia 1993; pp 15-22 Alan S M, Kyriakides T, Lawden M, Newman PK. Methylprednisolone in Multiple Sclerosis:  A comparison of Oral with Intravenous Therapy at Equivalent High Doses.  Journal of Neurology, Neurosurgery and Psychiatry 1993; 56:1219-1220.
  10. Kyriakides T, Gabriel G, Drousiotou A, Meznaric-Petrusa M, Middleton L M.  Dystrophinopathy presenting as congenital muscular dystrophy. Neuromusc. Disord., 1994; 4: 4: pp 387-392.
  11. Kyriakides T, Silbert P, Kakulas B A. Cerebral amyloid angiopathy and intracerebral haemorrhage with special  reference to the pons.  Clinical Neuropathology 1994; 13: 2: 71-76.                                                                                                                                                                       
  12. Kyriakides T, Drousiotou A.  No structural or biochemical evidence for mitochondrial cytopathy in a case of alternating hemiplegia of childhood.  Annals of Neurology 1994;  36, No.5,  805-806.
  13. Yamout BI, Kyriakides T, Tamim W, Drousiotou A.  Myalgia, neuromyopathy and internalized capillaries: A steroid responsive  syndrome.  Acta Neurol Scand 1995; 91:294-296.
  14. Christodoulou K, Kyriakides T, Hristova A H, Georgiou D M, Kalaydjieva L, Yshpekova B, Ivanova T, Weber J L, Middleton L T.  Mapping of a distal form of spinal muscular atrophy with upper limb  Predominance to chromosome 7p.  Human Molecular Genetics, 1995; 4, No  9, 1629-1632.
  15. Noguchi S, McNally E, Ben Othmane K, Hagiwara Y, Mizuno Y, Yoshida M,Yamamoto H, Bφnnemann C G, Gussoni E, Denton P H, Kyriakides T,     Middleton L T, Hentati F, Ben Hamida M, Nonaka I, Vance J M, Kunkel L M, Ozawa E.
  16.   Mutations in the dystrophin-associated protein γ-sarcoglycan in chromosome 13 muscular dystrophy.    Science, 1995; 270: 819-822.
  17. Kyriacou K, Kassianides B, Hadjisavvas A, Middleton L, Kyriakides T. The role of electron microscopy in the diagnosis of non-neoplastic muscle diseases. Ultrastructural Pathology 1997; 21:243-252
  18. Drousioutou A, Ioannou P, Georgiou T, Mavrikiou E, Christopoulos G, Kyriakides T, Voyasianos M, Argyriou A, Middleton L.  eonatal screening for Duchenne Muscular Dystrophy: a novel  semiquantitative application of bioluminescence test for creatine kinase in  a  pilot     national program in Cyprus.  Genetic Testing 1998; 2: 55-60                                                                                                                                  
  19. Kyriakides T, Chrystodoulou K. Zamba E, Middleton L.  Hereditary motor neuronopathies; clinical, neurophysiological and genetic aspects. Acta Myologica 1998; 2: 55-58
  20. Kyriacou K, Mikellidou C, Hadjianastasiou, Middleton L, Panousopoulos A, Kyriakides T. Ultrastructural Diagnosis of Mitochondrial Encephalomyopathies revisited.   Ultrastructural Pathology 1999; 23: 163-170
  21. Middleton L, Christodoulou K, Mubaidin A, Zamba E, Tsingis M, Kyriakou K, Abu-Shei Kh S, Kyriakides T, Neocleous V, Georgiou DM, El-Khateeb M, Al- Qudah Al, Horany K.  Distal hereditary motor neuronopathy of the Jerash type.  Annals New York,  Academy Sciences 1999; 883: 65-68
  22. Christodoulou K, Zambe E, Tsingis M, Mubaidin A, Horani K, Abu-Sheik S, El-Khatteb M, Kyriakou K, Kyriakides T, Al-Qudan AK, Middleton L.   A novel form of distal hereditary motor neuronopathy maps to chromosome 9P21.1-12. Ann Neurol 2000, 48 (6) 877-84.
  23. Zamba E, Christodoulou K, Al-Qudah AK, Horani K, Kyriakides T, Middleton LT, Mubaidin A.  Autosomal recessive distal hereditary motor neuropathies.  ACTA MYOLOGICA 2001: XX-1, 53-56.
  24. Georgiou DM, Jedzejowska H, Ryniewicz B, Hansmanowa – Petrusewicz I, Zamba E, Kyriakides T, Christodoulou K, Middleton LT.  Molecular  genetic studies in autosomal recessive Charcot-Marie Tooth disease. ACTA  MYOLOGICA, XX-1, 35-38.
  25. Kyriakides T, Marquez B, Panousopoulos A, Kyriacou E, Kyriacou K. Amyloid myopathy:  evidence for mechanical injury to the sarcolemma. Clinical Neuropathology 2002, 21, 145-148.
  26. Georgiou DM, Zidar J, Korosec M, Middleton LT, Kyriakides T, Christodoulou  K.  A novel NF-L mutation Pro22 Ser is associated with CMT2 in a large  Slovenian family.  Neurogenetics 2002, 4(2); 93-96.
  27. Zamba Papanicolaou E, Christodoulou K, Christodoulou C, Kyriakides T, Middleton LT.  Hereditary motor neuronopathies. Revue Neurologic. 2002:  158, 12, 1220-1224.
  28. K Kyriacou and T Kyriakides. In Preedy V R; Peters T J editors, Skeletal muscle: pathology diagnosis and management of disease. Chapter 42: Diagnostic Electron Microscopy. Publ Greenwich Medical media, London 2002.Kleopas K, Papanicolaou E, Kyriakides T. Lumbar compressive myelopathy presenting as segmental motor neuron disease: Muscle Nerve – 2003 Jul ; 28 (1):69-73. Papathanasiou E, Zamba-Papanicolaou E, Pantzaris M, Kyriakides T, Papacostas S, Myrianthopoulou P, Pattichis C, Illiopoulos I, Piperidou. A method of assessing the function of the vestibular system Electromyogr Clin Neurophysiol. 2003 Oct-Nov;43(7):399-408
  29. Papathanasiou ES, Pantzaris M, Zamba-Papanicolaou E, Kyriakides T, Kleopa KA, liopoulos I, Piperidou C, Papacostas S. Neurogenic vestibular evoked potentials in the diagnosis of multiple sclerosis. Electromyogr Clin   Neurophysiol. 2004 Jul-Aug; 44(5):313-7.
  30. Kyriakides T, Drousiotou A, Panasopoulou A, Hadjisavvas A, Zenios A, Hadjigeorgiou G M, Kyriakou K. A comparative morphological study in 33 cases of respiratory chain encephalomyopathies.  Acta Myologica ,2003, 22 (2): 48-51.
  31. Kleopas K, Kyriakides T.  Lower lip dystonia: a new phenotypic variant of cranial  movement disorder. Movement Disorders 2004, 19 (6): 663-666.
  32. Papathanasiou ES, Zamba-Papanicolaou E, Pantzaris M, Kleopa K, Kyriakides T, Papacostas S, Pattichis C, Illiopoulos I, Piperidou C. Neurogenic vestibular evoked potentials using a tone pip auditory stimulus.  Electromyogr Clin Neurophysiol. 2004 April-May: 44(3): 167-73.
  33. Kleopa KA, Georgiou DM, Nicolaou P, Koutsou P, Papathanasiou ES, Kyriakides T, Christodoulou K. A novel PMP22 mutation Ser22Phe in a family with hereditary neuropathy with liability to pressure palsies and CMT1A phenotypes. Neurogenics. 2004  Sep; 5(3):171-5.
  34. Papathanasiou ES, Piperidou C, Iliopoulos I, Malekidou A, Katelari- Theocharidou E, Kyriakides T, Kleopa KA, Papacostas SS.  Neurogenic  vestibular evoked potentials in three cases of vestibular system dysfunction. Electromyogr Clin Neurophysiol. 2005 Jan-Feb;45(1):39-45.
  35. Kleopa KA, Kyriacou K, Zamba-Papanicolaou E, Kyriakides T. Reversible Inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease. Muscle Nerve. 2005 Feb: 31(2):260-5.
  36. Kyriacou K, Hadjisavvas A, Zenios A, Papacharalambous R, Kyriakides T. Morphological methods in the diagnosis of mitochondrial encephalomyopathies: the role of electron microscopy. Ultrastruct Pathol. 2005 May-Aug; 29(3-4):169-74.
  37. Papathanasiou ES, Piperidou C, Pantzaris M, Iliopoulos I, Petsa M, Kyriakides T, Kleopa KA, Papacostas SS. Vestibular symptoms and signs are correlated with abnormal neurogenic vestibular evoked potentials in   patients with multiple sclerosis. Electromyogr Clin Neurophysiol. 2005 June; 45(4):195-201.
  38. Sivakumar K, Kyriakides T, Puls I, Nicolson GA, Funalot B, Antonellis A, Sambuughin N, Christodoulou K, Beggs JL, Zamba-Papanicolaou E, Ionasescu V, Dalakas MC, Green ED, Fischbeck KH, Goldfarb LG.  Phenotypic spectrum of disorders associated with glucyl-tRNA synthetase mutations. Brain. 2005 Jul 13: 128:2304-14
  39. Kleopa KA, Zamba-Papanicolaou E, Alevra X, Nicolaou P, Georgiou DM, Hadjisavvas A, Kyriakides T, Christodoulou K.  Phenotypic and cellular expression of two novel connexin 32 mutations causing CMT1X. Neurology.  2006 Feb; 66(3):396-402.
  40. Kleopa KA, Drousiotou A, Mavrikiou E, Ormiston A, Kyriakides T. Naturally occurring utrophin correlates with disease severity in Duchenne muscular  dystrophy. Hum Mol Genet. 2006 May; 15(10):1623
  41. Kyriakou K, Kyriakides T.  Mitochondrial encephalomyopathies: a review of outine diagnostic methods with emphasis on the role of electron microscopy. J. Submicrosc. Cytol. Pathol., 38 (2-3), 201-208, 2006
  42. Pantelidou M, Zographos SE, Lederer CW, Kyriakides T, Pfaffl MW, Santama N. Differential expression of molecular motors in the motor cortex of sporadic  ALS. Neurobiol Dis. 2007 Jun; 26(3):577-89
  43. Antoniades L., Eftychiou C., Kyriakides T., Christodoulou K., Katritsis DG Malignant mutation in the lamin A/C gene causing progressive conduction system disease and early sudden death in a family with mild form of limb-girdle muscular dystrophy.J Interv. Card. Electrophysiol. 2007 Jun;19(1):1-7.
  44. Papacostas S, Malikides A, Petsa M, Kyriakides T Ten-year mortality from Creutzfeldt-Jakob disease in Cyprus. East Mediterr Health J. 2008 May-Jun; 14(3):715-9
  45. Dardiotis E., Koutsou P., Papanicolaou E., Vonta I., Kladi D., VassilopoulosD., Hadjigeorgiou G., Christodoulou K., Kyriakides T., Epidemiological,  clinical and genetic study of Familial Amyloidotic Polyneuropathy in Cyprus. Amyloid. 2009 Mar;16(1):32-7
  46. Dardiotis E, Koutsou P, Zamba-Papanicolaou E, Vonta I, Hadjivassiliou M, Hadjigeorgiou G,      Cariolou M, Christodoulou K, Kyriakides T.  Complement C1Q polymorphisms modulate onset in familial Amyloidotic  polyneuropathy TTR Val30Met.  J Neurol Sci. 2009 Sep 15;284 (1-2):158
  47. Kyriakides T, Angelini C, Schaefer J, Sacconi S, Siciliano G, Vilchez JJ,Hilton-Jones D; European Federation of Neurological Societies. EFNS guidelines on  the diagnostic approach  to pauci- or asymptomatic hyperCKemia. Eur J Neurol. 2010  Jun 1;17(6):767-73.
  48. Nicolaou P, Zamba-Papanicolaou E, Koutsou P, Kleopa KA, Georghiou A, Hadjigeorgiou G, Papadimitriou A, Kyriakides T, Christodoulou K. Charcot-Marie-Tooth disease in Cyprus: epidemiological, clinical and genetic characteristics. Neuroepidemiology. 2010; 35(3):171-7
  49. Kyriakides T, Papacostas S, Papanicolaou E, Bagdades E, Papathanasiou ES. Sleep hypoventilation syndrome and respiratory failure due to multifocal motor neuropathy with conduction block. Muscle Nerve. 2011 Apr;43    (4):610-4.

 

Book Contributions (2006-2011);


Gilhus: European Handbook of Neurological Management: Volume 2, 2e - ch19
CHAPTER 19
Diagnostic approach to pauci- or asymptomatic hyperCKemia
T. Kyriakides,1 C. Angelini,2 J. Schaefer,3 S. Sacconi,4 G. Siciliano,5 J. J. Vilchez,6 and D. Hilton-Jones7

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Research Grants

1. European Regional Development Fund and the Republic of Cyprus through the Research and Innovation Foundation (Project: POST-DOC/0718/0113) According to the Alzheimer Disease (AD) amyloid ...

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