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Mouse Facility

Selected Publications

  1. AAV9-mediated Schwann cell-targeted gene therapy rescues a model of demyelinating neuropathy, Alexia Kagiava, Christos Karaiskos, Jan Richter, Christina Tryfonos, Matthew J Jennings, Amanda J Heslegrave, Irene Sargiannidou, Marina Stavrou, Henrik Zetterberg, Mary M Reilly, Christina Christodoulou, Rita Horvath, Kleopas A Kleopa, Gene Ther. 2021 Nov;28(10-11):659-675. doi: 10.1038/s41434-021-00250-0. Epub 2021 Mar 10
  2. Gene therapy after onset of neuropathy provides therapeutic benefit in a model of CMT1X Kagiava A, Karaiskos C, Richter J, Tryfonos C, Rossor A, Reilly M, Sargiannidou I, Christodoulou C, Kleopa KAHuman Molecular Genetics, August 2019
  3. Sequential Role of SOXB2 Factors in GABAergic Neuron Specification of the Dorsal Midbrain Makrides N, Panayiotou E, Fanis P, Karaiskos C, Lapathitis G, Malas S. Front Mol Neurosci. 2018 May 8. doi: 10.3389/fnmol.2018.00152 PMID: 29867344
  4. Regulatory role of oligodendrocyte gap junctions in inflammatory demyelination Papaneophytou CP, Georgiou E, Karaiskos C, Sargiannidou I, Markoullis K, Freidin MM, Abrams CK, Kleopa KA Glia. 2018 Oct 16. doi: 10.1002/glia.23513 PMID: 30325069
  5. Intrathecal gene therapy in mouse models expressing CMT1X mutations Kagiava A, Karaiskos C, Richter J, Tryfonos C, Lapathitis G, Sargiannidou I, Christodoulou C, Kleopa KA Hum Mol Genet. 2018 Feb 14. doi: 10.1093/hmg/ddy056. PMID: 29462293
  6. Systemic inflammation disrupts oligodendrocyte gap junctions and induces ER stress in a model of CNS manifestations of X-linked Charcot-Marie-Tooth disease Olympiou M, Sargiannidou I, Markoullis K, Karaiskos C, Kagiava A, Kyriacoudi S, Abrams CK, Kleopa KA Acta neuropathol Commun. 2016 Sep 1;4(1):95. doi: 10.1186/s40478-016-0369-5. PMID: 27585976
  7. Intrathecal gene therapy rescues a model of demyelinating peripheral neuropathy Kagiava A, Sargiannidou I, Theophilidis G, Karaiskos C, Richter J, Bashiardes S, Schiza N, Nearchou M, Christodoulou C, Scherer SS, Kleopa KA Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2421-9. doi: 10.1073/pnas.1522202113. Epub 2016 Mar 28. PMID: 27035961
  8. Transgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model Schiza N, Sargiannidou I, Kagiava A, Karaiskos C, Nearchou M, Kleopa KA. Hum Mol Genet. 2015 Apr 1;24(7):2049-64. doi: 10.1093/hmg/ddu725. Epub 2014 Dec 18. PMID: 25524707
  9. In vivo monitoring of the inflammatory response in a stented mouse aorta model Kapnisis KK, Pitsillides CM, Prokopi MS, Lapathitis G, Karaiskos C, Eleftheriou PC, Brott BC, Anderson PG, Lemons JE, Anayiotos AS.J Biomed Mater Res A. 2016 Jan;104(1):227-38. doi: 10.1002/jbm.a.35560. Epub 2015 Sep 18. PMID: 26362825
  10. Evidence for activation of the unfolded protein response in collagen IV nephropathies Pieri M, Stefanou C, Zaravinos A, Erguler K, Stylianou K, Lapathitis G, Karaiskos C, Savva I, Paraskeva R, Dweep H, Sticht C, Anastasiadou N, Zouvani I, Goumenos D, Felekkis K, Saleem M, Voskarides K, Gretz N, Deltas C.J Am Soc Nephrol. 2014 Feb;25(2):260-75. doi: 10.1681/ASN.2012121217. Epub 2013 Nov 21. PMID: 2426279


International Oral Presentation:

At 18th United European Gastroenterology Week (UEGW 2010, 23- 27 October, Barcelona).
Defective macrophage subpopulations in Crohn's Disease: Role in persistence of bacteria in lamina propria macrophages 
C. Karaiskos, B. N. Hudspith, T. R. Elliott, N. B. Rayment, V. Avgousti, J. Brostoff, J. D. Sanderson

winner