Athina Theodosiou

Academic Staff

Current Position

Associate Scientist /Bioinformatician, Department of Cytogenetics & Genomics

The Cyprus Institute of Neurology and Genetics


BSc in Biology, Aristotle University of Thessaloniki, School of Exact Science, 2005
MSc in Bioinformatics, University of Manchester, Faculty of Life Science, 2006
PhD in Bioinformatics, PhD program in Molecular Biology, University of Cyprus, Department of Biological Sciences, Bioinformatics Research Laboratory, 2015

Academic Appointments:

  • 1/08/2014-present. Bioinformatics Laboratory Scientific Officer at The Cyprus Institute of Neurology and Genetics, Department of Cytogenetics and Genomics.
  • 31/05/2013-31/07/2013. Research associate for GRANATUM project ( - a social collaborative working space semantically interlinking biomedical researchers, knowledge and data for the design and execution of in-silico models and experiments in cancer chemoprevention. 
  • 01/09/2009-30/06/2013. Teaching Assistant (TA). Introduction in Bioinformatics and  Principles and methods in Bioinformatics (course and lab).University of Cyprus, Department of Biological Sciences. 
  • December 2006 – May 2009. Bioinformatics Research assistant at the Bioinformatics laboratory of the Biomedical Research Foundation of the Academy of Athens (BRFAA). Greece 

Research Interests

  • Genetic investigation of undiagnosed patients using Next Generation Sequencing
  • Genetic investigation of high risk pregnancies and infertility problems with preimplantation genetic sequencing (NGS)
  • Bioinformatics sequence analysis
  • Transmembrane proteins and co-translational folding
  • Evolutionary Bioinformatics


Dr. Athina Theodosiou is the Bioinformatician of the Cytogenetics and Genomics Department at the Cyprus Institute of Neurology and Genetics (CING). The Department offers diagnostic services, research and educational programs and also has double accreditation from the College of American Pathologists and with ISO 15189. 
Dr. Theodosiou was born in Nicosia and has obtained her BSc in Biology from Aristotle University of Thessaloniki in 2005, a MSc in Bioinformatics from University of Manchester in 2006 and a PhD in Bioinformatics (PhD thesis: Probing the role of rare codons in coding sequences of Escherichia coli) in 2015 from University of Cyprus.
She was employed at the Department of Cytogenetics and Genomics in 2014, as Laboratory Scientific Officer and involved in several research projects of the Department including Exome and targeted NGS analysis as well as the PGS bioinformatics analysis. Moreover, she is involved in many research grant proposals of the Department. She is also a lecturer at the Cyprus School of Molecular Medicine (CSMM) contributing to the Bioinformatics course offered by the Bioinformatics group at CING. 
She is participating in many Bioinformatics workshops and conferences and she has recently joined the organising committee of the Hellenic Bioinformatics conference.

Selected Publications:

  1. Alexandrou A,  Papaevripidou I, Alexandrou I, Theodosiou A, Evangelidou P,  Kousoulidou L, Tanteles G, Christophidou‐Anastasiadou V, Sismani C. (2018) De novo mosaic MECP2 mutation in a female with Rett syndrome. Clinical case reports
  2. Aristidou C, Theodosiou A, Bak M, Mehrjouy M. M., Constantinou E, Alexandrou A, Papaevripidou I, Anastasiadou V. Skordis N, Kitsiou-Tzeli S, Tommerup N, Sismani C. (2018) Position effect, cryptic complexity, and direct gene disruption as disease mechanisms in de novo apparently balanced translocation cases. . PLOS ONE 13(10).e0205298
  3. Aristidou C, Theodosiou A, Ketoni A, Bak M, M.Mehrjouy, Tommerup N, Sismani C. (2018) Cryptic breakpoint identified by whole-genome mate pair sequencing in a rare paternally inherited complex chromosomal rearrangements. Molecular Cytogenetics 11:34 
  4. Aristidou C, Koufaris C, Theodosiou A, Bak M, Mehrjouy M, Behjati F, Tanteles G, Anastasiadou V, Tommerup N, Sismani C. (2016) Accurate breakpoint mapping in apparently balanced translocation families with discordant phenotypes using whole genome mate-pair sequencing. PLOS ONE 12(3): e0174190 
  5. Theodosiou A. and Promponas VJ*. (2012). LaTcOm: a web server for visualizing rare codon clusters in coding sequences. Bioinformatics, 28(4):591-2. 
  6. Attwood, T.K., Coletta, A., Muirhead, G., Pavlopoulou, A., Philippou, P.B., Popov, I., Roma-Mateo, C., Theodosiou, A. & Mitchell, A. (2012) «The PRINTS database: a fine-grained protein sequence annotation and analysis resource - its status in 2012.» Database, in press. 
  7. Theodosiou A., Arhondakis S., Baumann M., Kossida S. (2009). Evolutionary scenarios of Notch proteins. Mol.Bio.Evol. 26(7):1631-40. 
winner aashe copernicus