London Business School (LBS), Masters in Business Administration
University of London, University College, PhD in Molecular Immunology
University of London, Imperial College, BSc (Hons) Biochemistry
Research Interests
Genotype/phenotype correlation studies for β-thalasemia and HbH-disease patients
Reactivation of fetal hemoglobin by pharmacological agents for the treatment of β-hemoglobinpathies
Investigation of the mechanism of action of HbF inducers through proteomic studies
Studies on the molecular basis of non-deletional hereditary persistence of fetal hemoglobin
Investigation of unusual cases of β-type hemoglobinopathies
Investigation of the effect of metals on the HbF inducing action of hydroxyurea
Biography
Voskou S, Aslan M, Fanis P, Phylactides M, Kleanthous M. Oxidative stress in β-thalassaemia and sickle cell disease. Redox Biol. 2015 Dec;6:226-39.
Fanis P, Kousiappa I, Phylactides M, Kleanthous M. Genotyping of BCL11A and HBS1L-MYB SNPs associated with fetal haemoglobin levels: a SNaPshot minisequencing approach. BMC Genomics. 2014 Feb 6;15:108.
Kyrri AR, Kalogerou E, Loizidou D, Ioannou C, Makariou C, Kythreotis L, Phylactides M, Kountouris P, Angastiniotis M, Modell B, Kleanthous M. The changing epidemiology of β-thalassemia in the Greek-Cypriot population. Hemoglobin. 2013;37(5):435-43.
Borg J, Phylactides M, Bartsakoulia M, Tafrali C, Lederer C, Felice AE, Papachatzopoulou A, Kourakli A, Stavrou EF, Christou S, Hou J, Karkabouna S, Lappa-Manakou C, Ozgur Z, van Ijcken W, von Lindern M, Grosveld FG, Georgitsi M, Kleanthous M, Philipsen S, Patrinos GP. KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients. Pharmacogenomics. 2012 Oct;13(13):1487-500. doi: 10.2217/pgs.12.125.
Borg J, Phylactides M, Bartsakoulia M, Tafrali C, Lederer C, Felice AE, Papachatzopoulou A, Kourakli A, Stavrou EF, Christou S, Hou J, Karkabouna S, Lappa-Manakou C, Ozgur Z, van Ijcken W, von Lindern M, Grosveld FG, Georgitsi M, Kleanthous M, Philipsen S, Patrinos GP. KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients. Pharmacogenomics. 2012 Oct;13(13):1487-500.
Borg J, Papadopoulos P, Georgitsi M, Gutiérrez L, Grech G, Fanis P, Phylactides M, Verkerk AJ, van der Spek PJ, Scerri CA, Cassar W, Galdies R, van Ijcken W, Ozgür Z, Gillemans N, Hou J, Bugeja M, Grosveld FG, von Lindern M, Felice AE, Patrinos GP, Philipsen S. Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Nat Genet. 2010 Sep;42(9):801-5.
Spyrou P, Phylactides M, Lederer CW, Kithreotis L, Kirri A, Christou S, Kkolou E, Kanavakis E, Anagnou NP, Stamatoyannopoulos G, Kleanthous M. Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model. Blood Cells Mol Dis. 2010 Mar-Apr;44(2):100-6.
McCarthy VA, Ott CJ, Phylactides M, Harris A. Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression. Biochim Biophys Acta. 2009 Nov-Dec;1789(11-12):709-18.
Kyrri AR, Felekis X, Kalogerou E, Wild BJ, Kythreotis L, Phylactides M, Kleanthous M. Hemoglobin variants in Cyprus. Hemoglobin. 2009;33(2):81-94.
Chassanidis C, Kalamaras A, Phylactides M, Pourfarzad F, Likousi S, Maroulis V, Papadakis MN, Vamvakopoulos NK, Aleporou-Marinou V, Patrinos GP, Kollia P. The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter. Ann Hematol. 2009 Jun;88(6):549-55
Kleanthous M, Phylactides, M. Thalassemia and its relevance to personalized medicine. Personalized Medicine. 2008, 5(2),141-154, 2008
Felekis X, Phylactides M, Drousiotou A, Christou S, Kyrri A, Kyriacou K, Kalogerou E, Christopoulos G, Kleanthous M. Hb Agrinio [alpha29 (B10) LeuPro (alpha2)] in Combination with - -(MED I) Results in a Severe Form of Hb H Disease. Hemoglobin 2008; 32(3): 237-46
Pavlou E, Phylactides M, Kyrri A, Kalogerou E, Makariou C, Georgiou I, Kleanthous M. Delta-thalassaemia in Cyprus. Hemoglobin 2006; 30(4):455-62
Mouchel N, Henstra SA, McCarthy VA, Williams SH, Phylactides M, Harris A. HNF1alpha is involved in tissue-specific regulation of CFTR gene expression. Biochem J. 2004 Mar 15;378(Pt 3):909-18.
Phylactides M, Rowntree R, Nuthall H, Ussery D, Wheeler A, Harris A. Evaluation of potential regulatory elements identified as DNase I hypersensitive sites in the CFTR gene. Eur J Biochem. 2002 Jan;269(2):553-9.
Rowntree RK, Vassaux G, McDowell TL, Howe S, McGuigan A, Phylactides M, Huxley C, Harris A. An element in intron 1 of the CFTR gene augments intestinal expression in vivo. Hum Mol Genet. 2001 Jul 1;10(14):1455-64.
Tkalcevic J, Novelli M, Phylactides M, Iredale JP, Segal AW, Roes J. Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity. 2000 Feb;12(2):201-10.
Phylactides M. Molecular biology series 3. Tools of molecular biology: gene cloning. Br J Hosp Med. 1997 Jan 15-Feb 5;57(1-2):49-50.
Awards
Framework program for research, technological development and innovation 2009-2010 projects:
Genotype/phenotype correlation studies for HbH-disease patients and all the β-thalassemia patients in Cyprus. Call Identifier: ΥΓΕΙΑ/ΔΥΓΕΙΑ/0311(ΒΙΕ)/39. Total Project Budget: € 179928
Chemoinformatic solutions for the identification and optimization of agents for the treatment of thalassemia. Call Identifier: ΥΓΕΙΑ/ΒΙΟΣ/0609(ΒΙΕ)/13.Total project Budget: € 179936
Screening and delineation of the molecular mechanism of action of novel agents for the treatment of β-thalassemia. Call Identifier: ΥΓΕΙΑ/ΒΙΟΣ/0609(ΒΕ)/01.Total project Budget: € 139948
HU-Pharmgk: Pharmacogenomic analysis of β-thalassemia patients under Hydroxyurea treatment: Implications for β-thalassemia therapeutics, 2007-2009. RPF ΠΔΕ/0406 (79,200 CYP).
Fellowships:
UCL Special Trustees Fund fellowship for PhD students