Andreas Hadjisavvas

Associate Professor

Current Position

Scientist, Department of Electron Microscopy and Molecular Pathology, The Cyprus Institute of Neurology and Genetics

Associate Professor, Cyprus School of Molecular Medicine

Research Interests

• Cancer genetics
• Cancer proteomics
• Mitochondrial disorders

 

Biography

Dr. Andreas Hadjisavvas was born in Akaki in Cyprus in 1967. Following his graduation from the Kykkos A Lyceum in Nicosia and the completion of his military service Dr. Hadjisavvas went to London for his university studies. He received his BSc Honours degree in Biochemistry from the University of East London and his MSc degree in Medical Biochemistry from Brunel University. In 1994 he return to Cyprus where he was hired in the Department of Electron Microscope/Molecular pathology. He was actually the first employee of the department working in the field of molecular biology and genetics. During these early days, he was responsible to equip and organize the department so that it may embark working in this very demanding field. In the meantime he was registered for his PhD with Brunel University UK which he succesfully defend in 2001 in the field of cancer genetics. Following this success, and building on the work carried out during his thesis work, the department began offering a range of diagnostic services investigating  cancer genetic syndromes in Cyprus.
Dr. Hadjisavvas has been very active in research in the fields of cancer genetics, epidemiology as well in the field of nephrology, mitochondrial and neuromuscular disorders. He has participated in more than 20 grants that were completed, either as co-investigator, collaborator or as prinicipal investigator. Currently he holds 5 grants as prinicipal investigator and in another 10 as co-investigator. He has published more than 28 original research articles and two chapters in books. He serves as reviewer for many international scientific journals. He has supervised both PhD and Master students that have succesfully completed their studies. In 2009 Brunel University awarded him the title of Adjunct Professor.  He was a founding member of the Cyprus Society of Human Genetics in 2004 and since then has been an elected member of its board of Directors. He is also currently on the BoD of the Human Genome Variation Society and represents Cyprus as the country node to the Human Variome Project. Over time, he has been appointed by the Counsil of Ministers to various National Committes. He has actively participated in the organization of several international scientific conferences and symposiums and has been invited to deliver many presentations at local and international scientific seminars and meetings

 

Selected publications:


1. MA Loizidou, A Hadjisavvas, JP Ioannidis, K Kyriacou. Replication of genome-wide discovered breast cancer risk loci in the Cypriot population. Breast Cancer Res Treat. 128(1):267-72, 2011.
2. A. Hadjissavas, M.A. Loizidou, N. Middleton, T. Michael, R. Papachristoforou, E. Kakouri, M. Daniel, P. Papadopoulos, S. Malas, Y. Marcou, K. Kyriacou. An investigation of breast cancer risk factors in Cyprus: a case control study. BMC Cancer. 2010 Aug 23;10:447.
3. D.P. Gale, E.G de Jorge, H.T. Cook, R. Martinez-Barricarte, A. Hadjisavvas, A.G. McLean, C.D. Pusey, A. Pierides, K. Kyriacou, Y. Athanasiou, K. Voskarides, C. Deltas, A. Palmer, V. Frémeaux-Bacchi, S.R. de Cordoba, P.H. Maxwell, M.C. Pickering. Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. Lancet. 2010;376(9743):794-801.
4. C.W. Sutton, N. Rustogi, C. Gurkan, A. Scally, M.A. Loizidou, A. Hadjisavvas, K. Kyriacou. Quantitative proteomic profiling of matched normal and tumor breast tissues. J Proteome Res. 2010; 9(8): 3891-902
5. Loizidou M, Cariolou M, Neuhausen SL, Newbold RF, Marcou Y, Michael T, Kakouri E, Daniel M, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. Breast Cancer Res Treat. 121(1):147-56, 2010.
6. Loizidou MA, Michael T, Neuhausen SL, Newbold RF, Marcou Y, Kakouri E, Daniel M, Papadopoulos P, Malas S, Hadjisavvas A, Kyriacou K. DNA-repair genetic polymorphisms and risk of breast cancer in Cyprus. Breast Cancer Res Treat. 115:623-627, 2009.
7. Loizidou MA, Michael T, Neuhausen SL, Newbold RF, Marcou Y, Kakouri E, Daniel M, Papadopoulos P, Malas S, Kyriacou K, Hadjisavvas A. Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus. Breast Cancer Res Treat. 112(3): 575-9, 2008.
8. Zouvani I, Aristodemou S, Hadjisavvas A, Michael T, Vassiliou M, Patsias C, Pierides A, Ioannou K, Kyriacou K. Incidence of thin basement membrane nephropathy in 990 consecutive renal biopsies examined with electron microscopy. Ultrastruct Pathol. 2008; 32(6):221-6.
9. Sargiannidou I, Vavlitou N, Aristodemou S, Hadjisavvas A, Kyriacou K, Scherer S, Kleopa K. Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defects. Journal of Neuroscience. 29(15):4736-49, 2009.

 

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