Publications

Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model.

Spyrou P, Phylactides M, Lederer CW, Kithreotis L, Kirri A, Christou S, Kkolou E, Kanavakis E, Anagnou NP, Stamatoyannopoulos G, Kleanthous M.

Blood Cells Mol Dis. 2010 Mar-Apr;44(2):100-6. Epub 2009 Nov 14.

PMID: 19914848

Risk/benefit assessment, advantages over other drugs and targeting methods in the use of deferiprone as a pharmaceutical antioxidant in iron loading and non iron loading conditions.

Kontoghiorghes GJ, Efstathiou A, Kleanthous M, Michaelides Y, Kolnagou A.

Hemoglobin. 2009;33(5):386-97.

PMID: 19814684

An electronic infrastructure for research and treatment of the thalassemias and other hemoglobinopathies: the Euro-mediterranean ITHANET project.

Lederer CW, Basak AN, Aydinok Y, Christou S, El-Beshlawy A, Eleftheriou A, Fattoum S, Felice AE, Fibach E, Galanello R, Gambari R, Gavrila L, Giordano PC, Grosveld F, Hassapopoulou H, Hladka E, Kanavakis E, Locatelli F, Old J, Patrinos GP, Romeo G, Taher A, Traeger-Synodinos J, Vassiliou P, Villegas A, Voskaridou E, Wajcman H, Zafeiropoulos A, Kleanthous M.

Hemoglobin. 2009;33(3):163-76.

PMID: 19657830

Prenatal diagnosis of hemoglobin disorders: present and future strategies.

Harteveld CL, Kleanthous M, Traeger-Synodinos J.

Clin Biochem. 2009 Dec;42(18):1767-79. Epub 2009 Jul 14. Review.

PMID: 19607819

Hemoglobin variants in Cyprus.

Kyrri AR, Felekis X, Kalogerou E, Wild BJ, Kythreotis L, Phylactides M, Kleanthous M.

Hemoglobin. 2009;33(2):81-94.

PMID: 19373583

Molecular basis of thalassemia intermedia in Iran.

Akbari MT, Izadi P, Izadyar M, Kyriacou K, Kleanthous M.

Hemoglobin. 2008;32(5):462-70.

PMID: 18932071

Arrayed primer extension for the noninvasive prenatal diagnosis of beta-thalassemia based on detection of single nucleotide polymorphisms.

Papasavva T, Kalikas I, Kyrri A, Kleanthous M.

Ann N Y Acad Sci. 2008 Aug;1137:302-8.

PMID: 18837964

Hb Agrinio [alpha29(B10)Le-->uPro (alpha2)] in combination with --(MED I). Results in a severe form of Hb H disease.

Felekis X, Phylactides M, Drousiotou A, Christou S, Kyrri A, Kyriakou K, Kalogerou E, Christopoulos G, Kleanthous M.

Hemoglobin. 2008;32(3):237-46.

PMID: 18473239

Multicenter study of the molecular basis of thalassemia intermedia in different ethnic populations.

Verma IC, Kleanthous M, Saxena R, Fucharoen S, Winichagoon P, Raizuddin S, Khan SN, Akbari MT, Izadyar M, Kotea N, Old JM, Ioannou PA, Khan B.

Hemoglobin. 2007;31(4):439-52.

PMID: 17994378

10.

An overview of current microarray-based human globin gene mutation detection methods.

Cremonesi L, Ferrari M, Giordano PC, Harteveld CL, Kleanthous M, Papasavva T, Patrinos GP, Traeger-Synodinos J.

Hemoglobin. 2007;31(3):289-311. Review.

PMID: 17654067

11.

Noninvasive prenatal diagnostic assay for the detection of beta-thalassemia.

Papasavva T, Kalakoutis G, Kalikas I, Neokli E, Papacharalambous S, Kyrri A, Kleanthous M.

Ann N Y Acad Sci. 2006 Sep;1075:148-53.

PMID: 17108205

12.

Delta-thalassemia in Cyprus.

Pavlou E, Phylactides M, Kyrri A, Kalogerou E, Makariou C, Georgiou I, Kleanthous M.

Hemoglobin. 2006;30(4):455-62.

PMID: 16987800

13.

The impact of genotype on endocrine complications in thalassaemia major.

Skordis N, Michaelidou M, Savva SC, Ioannou Y, Rousounides A, Kleanthous M, Skordos G, Christou S.

Eur J Haematol. 2006 Aug;77(2):150-6. Epub 2006 Jun 23.

PMID: 16800840

14.

The cypriot and Iranian National Mutation Frequency Databases.

Kleanthous M, Patsalis PC, Drousiotou A, Motazacker M, Christodoulou K, Cariolou M, Baysal E, Khrizi K, Moghimi B, Pourfarzad F, van Baal S, Deltas C, Najmabadi H, Patrinos GP.

Hum Mutat. 2006 Jun;27(6):598-9.

PMID: 16705699

15.

The impact of iron overload and genotype on gonadal function in women with thalassaemia major.

Skordis N, Gourni M, Kanaris C, Toumba M, Kleanthous M, Karatzia N, Pavlides N, Angastiniotis M.

Pediatr Endocrinol Rev. 2004 Dec;2 Suppl 2:292-5.

PMID: 16462714

16.

Novel polymorphisms at codons 146 and 151 in the prion protein gene of Cyprus goats, and their association with natural scrapie.

Papasavva-Stylianou P, Kleanthous M, Toumazos P, Mavrikiou P, Loucaides P.

Vet J. 2007 Mar;173(2):459-62. Epub 2005 Nov 28.

PMID: 16314132

17.

Identification of alpha-thalassemia mutations in Iranian individuals with abnormal hematological indices and normal Hb A2.

Gohari LH, Petrou M, Felekis X, Christopoulos G, Kleanthous M.

Hemoglobin. 2003 May;27(2):129-32. No abstract available.

PMID: 12779276

18.

Hb Limassol [beta8(A5)Lys-->Asn]: a new hemoglobin variant.

Kyrri A, Felekis X, Kalogerou E, Christopoulos G, Makariou C, Loizidou D, Kleanthous M.

Hemoglobin. 2001 Nov;25(4):421-4. No abstract available.

PMID: 11791876

19.

A multi-center study in order to further define the molecular basis of beta-thalassemia in Thailand, Pakistan, Sri Lanka, Mauritius, Syria, and India, and to develop a simple molecular diagnostic strategy by amplification refractory mutation system-polymerase chain reaction.

Old JM, Khan SN, Verma I, Fucharoen S, Kleanthous M, Ioannou P, Kotea N, Fisher C, Riazuddin S, Saxena R, Winichagoon P, Kyriacou K, Al-Quobaili F, Khan B.

Hemoglobin. 2001 Nov;25(4):397-407.

PMID: 11791873

20.

Alpha-thalassaemia prenatal diagnosis by two PCR-based methods.

Kleanthous M, Kyriacou K, Kyrri A, Kalogerou E, Vassiliades P, Drousiotou A, Kallikas I, Ioannou P, Angastiniotis M.

Prenat Diagn. 2001 May;21(5):413-7.

PMID: 11360286

21.

Identification of a novel beta0-thalassemia mutation, codons 80/81 (-C), in an Iranian family.

Feleki X, Najmabadi H, Karimi-Nejad R, Christopoulos G, Kleanthous M.

Hemoglobin. 2000 Nov;24(4):319-21. No abstract available.

PMID: 11186262