Study of gene function, molecular mechanisms and pathways of diseases.
Contribution to the development of therapeutic approaches for neurodegenerative disease.
Dr Paschalis Nicolaou completed his BSc degree in Chemistry at the Aristotle University of Thessaloniki in Greece and his PhD in Medical Genetics at the School of Health Sciences of the University of Thessaly Greece and the Neurogenetics Department of Cyprus Institute of Neurology and Genetics (CING) in Cyprus. He is employed at the CING since September 2002. He is Scientist at the Neurogenetics Department and he is involved in diagnostic and translational research projects on neurogenetic diseases. He participated in six research Grants and he is an author of 11 scientific publications. He is a Lecturer at the Cyprus School of Molecular Medicine of the CING and he supervised several MSc and PhD students. He is a member of the Cyprus Society of Human Genetics since 2004.
Chairta P, Nicolaou P, Christodoulou K.Genomic and Genetic studies of Systemic Sclerosis: a systematic review. Human Immunol 2017 Feb; 78(2):153-165.
Nicolaou P, Cianchetti C, Minaidou A, Marrosu G, Zamba-Papanicolaou E, Middleton L, Christodoulou K. A novel LRSAM1 mutation is associated with autosomal dominant axonal Charcot-Marie-Tooth disease. Eur J Hum Genet. 2012 Jul 11. doi: 10.1038/ejhg.2012.146. [Epub ahead of print] PMID: 22781092
Mastroyiannopoulos NP, Nicolaou P, Anayasa M, Uney JB, Phylactou LA. Down-regulation of myogenin can reverse terminal muscle cell differentiation. PLoS One. 2012;7(1):e29896. Epub 2012 Jan 3. PMID: 22386940
Nicolaou P, Zamba-Papanicolaou E, Koutsou P, Kleopa AK, Georghiou A, Hadjigeorgiou G, Papadimitriou A, Kyriakides Th, Christodoulou K. Charcot-Marie-Tooth disease in Cyprus: epidemiological, clinical and genetic characteristics. Neuroepidemiology. 2010;35(3):171-7. Epub 2010 Jun 23. PMID: 20571287
Nicolaou P, Georghiou A, Votsi C, Middleton LT, Zamba-Papanicolaou E and Christodoulou K. A novel c.5308_5311delGAGA mutation in Senataxin in a Cypriot family with an autosomal recessive cerebellar ataxia. BMC Med Genet. 2008 Apr 14;9:28. PMID: 18405395
Kleopa KA, Zamba-Papanicolaou E, Alevra X, Nicolaou P, Georgiou DM, Hadjisavvas A, Kyriakides T, Christodoulou K. Phenotypic and cellular expression of two novel Connexin32 mutations causing CMT1X. Neurology. 2006 Feb 14;66(3):396-402. PMID: 16476939