CING Lectures: Proteases of filamentous fungi

16:00 – 17:00 h Alexander A. Osmolovskiy - Proteases of filamentous fungi: effect on proteins of the human hemostatic system and application
Deputy Dean for Academic Affairs, Lomonosov State University, Moscow

This presentation will be devoted to the original work on the study of the activity of micromycete proteinases in relation to human hemostasis proteins. The work of the scientific group of Moscow State University develops ideas about the ability of microscopic fungi to directly hydrolyze or activate, as a result of limited proteolysis, proteins and proenzymes of blood coagulation and fibrinolysis. The obtained preparations of extracellular enzymes of fungi have shown their effectiveness in comparison with analogues obtained from other sources and may be promising for the treatment and diagnosis of thromboembolic complications.
The talk will point out the benefits of fungi as producers of extracellular proteolytic enzymes, briefly cover the history of the issue, show strategies for finding producers of hemostatically active enzymes among micromycetes and search for targets of the effects of their proteases on hemostasis proteins developed at the Department of Microbiology of Moscow State University. Separately, the most interesting research group developments for the diagnosis of human plasma C protein and treatment of thrombophlebitis based on microscopic fungal proteinases will be presented.

Click here for more information regarding CING Lectures.