George Tanteles

Professor

Current Position

Professor, Cyprus School of Molecular Medicine
Head of the Clinical Genetics Clinic, The Cyprus Institute of Neurology & Genetics

 

Education

  • Apr 2012: Doctor of Medicine (DM) (Doctorate degree). Thesis title: Genetic and radiobiological causes of normal-tissue injuries following breast cancer radiotherapy. Awarded with distinction from the University of Leicester.
  • Nov 2010: Completion of training in Clinical Genetics leading to award of the Certificate of Completion of Training (CCT-UK). Certificate of recognition of training in Medical Genetics, Republic of Cyprus.
  • Dec 2004: Certificate of recognition of completion of training in General Pediatrics: Republic of Cyprus.
  • Oct 2003: Membership of the Royal College of Paediatrics and Child Health (MRCPCH).
  • Mar 1999: Ptychio Iatrikes (MD), University of Patras, School of Medicine, Patras, Greece.

 

Previous Academic appointments:

  • 2012: Honorary Visiting Clinical Fellow- Department of Cancer Studies and Molecular Medicine, University of Leicester, UK.
  • 2016: Senior Consultant in Clinical Genetics, at the Cyprus Institute of Neurology and Genetics.

 

Research Interests

  • Genetic and molecular characterisation of Cypriot patients with multiple malformation syndromes (MMS) of unknown aetiology (in collaboration with the Cytogenetics and Genomics department). 
  • Elucidation of genetic aetiology in undiagnosed patients with mitochondrial cytopathies (in collaboration with Neurology Clinic A and Electron Microscope/Molecular Pathology).
  • Development of a national registry on congenital anomalies, called CENSUS as a pilot project for a rare disease registry. 
  • Participation in the “Epi25 Collaborative for Large-Scale Whole Genome Sequencing in Epilepsy” project. (without funding) – Co-collaborators with Neurology Clinic B.
  • The epidemiology and genetic aetiology of Familial Amyloidotic Polyneuropathy Type I (ATTRV30M) in Cyprus. Funded by Global ASPIRE TTR (in collaboration with Neurology Clinic A).
  • Molecular characterisation of patients with ocular abnormalities and other congenital malformations using targeted sequencing.
  • Functional studies on a novel KIF1BP variant linked to Goldberg-Shprintzen syndrome. Funded by Telethon (2018-2019)
  • Participation in the EnGagE network (Enhancing Psychiatric Genetic Counselling, Testing and Training in Europe) funded by COST.
  • Full member of the ERN-ITHACA (European Reference Network On Rare Congenital Malformations And Rare Intellectual Disability).
  • Lipodystrophies, the clinic is a member of ECLip (European Lipodystrophies Patient Registry).

 

Biography

Professor George A. Tanteles is a consultant in Clinical Genetics and a Paediatrician. He holds a UK certificate of completion of training [CCT(UK)] in Clinical Genetics. As an established physician, he has extensive experience in all aspects of his discipline. His mission is to help translate information obtained by the wealth of various research discoveries such as disease gene identification to safeguard the wellbeing of his patients and their families. He always strives to provide his patients with safe, appropriate, efficacious, cost-effective and ethical care. He always aims to explain complex genetic concepts in ways that are meaningful and clear and always considers and evaluates the family history of an illness and any potential implications arising from this to his patient’s health or the health of the entire family. He has devoted many years in caring for his patient’s best interests. Dr Tanteles holds in addition to his Clinical Genetics specialty a UK membership in Paediatrics. He completed his doctorate degree with distinction at the University of Leicester looking at ‘the genetic basis of abnormal radiosensitivity in women receiving radiotherapy for breast cancer’. His thesis was awarded the prestigious Lauder prize for best DM thesis. His current research interests include the elucidation of the genetic basis of rare monogenic disorders, dysmorphology, skeletal dysplasias and the genetic basis of abnormal radiosensitivity. He has published more than 55 peer-reviewed research articles in the field of Clinical Genetics (h-index: 11). 

 

Selected Publications

  1. A Genome Wide Association Study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity. Barnett GC, Thompson D, Fachal L, Kerns S, Talbot C, Elliott RM, Dorling L, Coles CE, Dearnaley DP, Rosenstein BS, Vega A, Symonds P, Yarnold J, Baynes C, Michailidou K, Dennis J, Tyrer JP, Wilkinson JS, Gómez-Caamaño A, Tanteles GA, Platte R, Mayes R, Conroy D, Maranian M, Luccarini C, Gulliford SL, Sydes MR, Hall E, Haviland J, Misra V, Titley J, Bentzen SM, Pharoah PD, Burnet NG, Dunning AM, West CM. Radiother Oncol. 2014 May;111(2):178-85. 
  2. Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability. Grozeva D, Carss K, Spasic-Boskovic O, Tejada MI, Gecz J, Shaw M, Corbett M, Haan E, Thompson E, Friend K, Hussain Z, Hackett A, Field M, Renieri A, Stevenson R, Schwartz C, Floyd JA, Bentham J, Cosgrove C, Keavney B, Bhattacharya S; Italian X-linked Mental Retardation Project; UK10K Consortium; GOLD Consortium, Hurles M, Raymond FL. Hum Mutat. 2015 Dec;36(12):1197-204. 
  3. Microform holoprosencephaly with bilateral congenital elbow dislocation; increasing the phenotypic spectrum of Steinfeld syndrome. Jones GE, Robertson L, Maniyar A, Shammas C, Phelan MM, Vasudevan PC, Tanteles GA. Am J Med Genet A. 2016 Mar;170(3):754-9. 
  4. Accurate Breakpoint Mapping in Apparently Balanced Translocation Families with Discordant Phenotypes Using Whole Genome Mate-Pair Sequencing. Aristidou C, Koufaris C, Theodosiou A, Bak M, Mehrjouy MM, Behjati F, Tanteles G, Christophidou-Anastasiadou V, Tommerup N, Sismani C. PLoS One. 2017 Jan 10;12(1):e0169935.
  5. Ultra-rare genetic variation in the epilepsies: a whole-exome sequencing study of 17,606 individuals. Epi25 Collaborative, Yen-Chen Anne Feng, Daniel P. Howrigan, Liam E. Abbott, Katherine Tashman, Felecia Cerrato, Tarjinder Singh, Henrike Heyne, ….., Sabina Gallati, Savvas S. Papacostas, Ioanna Kousiappa, George A. Tanteles, Katalin Štěrbová, …... Daniel H. Lowenstein, David B. Goldstein, Holger Lerche, Samuel F. Berkovic, Benjamin M. Neale. (Accepted for publication to American Journal of Human Genetics). doi: https://doi.org/10.1101/525683.

 

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