Neurogenetics Department

Research

Research Projects are being conducted related to gene mapping, gene identification and mutation detection studies in a selection of neurological conditions Research Projects are being conducted related to gene mapping, gene identification and mutation detection studies in a selection of neurological conditions.

The department has the expertise to localize unknown disease genes by genome-wide linkage search. So far six neurogenetic and one nephrological disease genes have been mapped. Research programmes have been financially supported by the Muscular Dystrophy Association (MDA) of the United States, the French MDA (AFM), the European Union, UNOPS, MECC, the Planning Bureau / Government of Cyprus and the Cyprus Research Promotion Foundation. Several research programmes are organised in collaboration with other institutions in Europe, the United States and the Middle East.

The department became involved in the HUMAN GENOME PROJECT through a programme funded by the MDA (USA). The project continues and is focused on the identification of the gene involved in the pathogenesis of a novel form of hereditary motor neuronomathy (HMN-J) recently identified and mapped to chromosome 9p21.1-p12. The department in collaboration with the Sanger Centre that at the time had just been assigned to sequence chromosome 9, worked for the construction of the sequence ready counting map of the above region.

The Department is currently involved in research projects on Charcot‐Marie‐Tooth neuropathies, spinocerebellar ataxias, multiple sclerosis and type 2 diabetes.

Selected Publications

Demetriou CA, Heraclides A, Salafori C, Tanteles GA, Christodoulou K, Christou Y, Zamba-Papanicolaou E. Epidemiology of Huntington disease in Cyprus: a 20 year ...

Publications Archive

Original, peer reviewed articles 1. Theodorou L, Nicolaou P, Koutsou P, Georghiou A, Anastasiadou V, Tanteles G Kyriakides T, Zamba-Papanicolaou E, ...

Current Grants

1. Establishment of the Bioinformatics ERA Chair at the Cyprus Institute of Neurology and Genetics – BIORISE [Grant agreement number: ...

Previous Grants

1. Molecular genetic study of Friedreich’s ataxia; Funding body: Muscular Dystrophy Association (USA); Co-investigator; Support period: 05/1992 ...

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