CING Lectures: Genetics of Locomotor Disorderso

Genetics of Locomotor Disorders 
Prof Henry Houlden, PhD

Houlden, H; UCL Institute of Neurology & MRC Centre for Neuromuscular Diseases, UK 
Lefkos Middleton Amphitheater
Wednesday, 7th February 2018
16:00 – 17:00 hrs

Prof. Henry Houlden
(Senior Lecturer and Consultant Neurologist) 

Institute of Neurology
Queen Square
London
WC1N 3BG
 

Prof Houlden's clinical and laboratory research interest are neurodegeneration, peripheral nerve disease, ataxia, neurogenetics and neurorehabilitation.
The combination of genetic, functional cell biology and neuropathological methods is a particularly powerful approach for understanding neurological diseases and their pathological processes. Given the rapid advances in genetic technology and knowledge, the analysis of RNA, protein expression and protein interactions in human tissue will become central to neurological research. It is likely that the next 10 years will see the development of treatments for human diseases based on these advances. Therefore, the collection of clinically characterised neuropathological material is pivotal to future research. 
His research group is carrying out a programme of genetic and pathological investigations into human neurodegeneration. This has recently led to the identification of two ataxia genes, with ongoing work on a number of disease genes in ataxia, peripheral neuropathy, Parkinson's disease and dementia. These genetic and neuropathological studies integrating functional in vitro research will translate this research into disease modifying treatment for human diseases.
Methods used are Bioinformatic analysis, Gene expression profiling – tissue level, Genetic manipulation (including knockout/knockin), Genetically encoded reporters/indicators, Genetic screens, Genomic analyses, Histology, Immunohistochemistry, Linkage, mapping and positional cloning, Microarrays, Proteomic.

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